Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.50 |
| ▸ | EDNRA | P25101 | 6/20 | 0.50 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8977969 | 0.88 | EDNRB (0.49) | EDNRBEDNRAP2RY1NR1I2MEN1 | |
| SCHEMBL7849998 | 0.82 | EDNRA (0.69) | EDNRBEDNRAP2RY1MEN1KMT2A | |
| SCHEMBL7715903 | 0.81 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL7857284 | 0.78 | EDNRA (0.52) | EDNRBEDNRAHDAC6HDAC4HDAC1 | |
| SCHEMBL9063613 | 0.75 | EDNRA (0.72) | EDNRBEDNRAP2RY1HDAC6HDAC4 | |
| SCHEMBL6151679 | 0.75 | EDNRA (0.72) | EDNRBEDNRAP2RY1HDAC6HDAC4 | |
| SCHEMBL6324589 | 0.74 | EDNRA (0.48) | EDNRBEDNRAMETAP2METAP1 | |
| SCHEMBL7857440 | 0.72 | EDNRA (0.52) | EDNRBEDNRAP2RY1MEN1KMT2A | |
| SCHEMBL7849843 | 0.72 | EDNRA (0.52) | EDNRBEDNRAP2RY1MEN1KMT2A | |
| SCHEMBL7857532 | 0.72 | EDNRA (0.52) | EDNRBEDNRAP2RY1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514691-A | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin | IMMUNOPHARMACEUTICS, INC. (US) | 1996-05-07 | — | — | US | disclosed |