SCHEMBL8979017

SCHEMBL8979017

CCCCc1ccc(C#Cc2c(F)cc(C#Cc3ccc(C)cc3)cc2F)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 6/20 0.43
PTPN11 Q06124 1/20 0.38
PTPRO Q16827 1/20 0.38
HSD17B10 Q99714 2/20 0.37
TSHR P16473 1/20 0.37
SKP2 Q13309 1/20 0.36
IGF1R P08069 1/20 0.36
ALOX15 P16050 1/20 0.36
KCNH2 Q12809 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2A6 P11509 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
CNR2 P34972 1/20 0.36
ESR1 P03372 2/20 0.36
ADRA2A P08913 2/20 0.36
ADORA3 P0DMS8 2/20 0.36
TACR2 P21452 2/20 0.36
SLC6A2 P23975 2/20 0.36
SLC6A4 P31645 2/20 0.36
SLC6A3 Q01959 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8978832 1.00 FFAR1 (0.43) FFAR1PTPN11PTPROHSD17B10TSHR
SCHEMBL8979029 0.96 FFAR1 (0.42) FFAR1PTPN11PTPROHSD17B10TSHR
SCHEMBL8979096 0.96 FFAR1 (0.42) FFAR1PTPN11PTPROHSD17B10TSHR
SCHEMBL8978865 0.94 HSD17B10 (0.44) FFAR1PTPN11PTPROHSD17B10TSHR
SCHEMBL8978984 0.94 HSD17B10 (0.44) FFAR1PTPN11PTPROHSD17B10TSHR
SCHEMBL8978941 0.94 HSD17B10 (0.44) FFAR1PTPN11PTPROHSD17B10TSHR
SCHEMBL8979072 0.94 HSD17B10 (0.44) FFAR1PTPN11PTPROHSD17B10TSHR
SCHEMBL8978891 0.94 HSD17B10 (0.44) FFAR1PTPN11PTPROHSD17B10TSHR
SCHEMBL8979095 0.94 HSD17B10 (0.44) FFAR1PTPN11PTPROHSD17B10TSHR
SCHEMBL8979178 0.94 HSD17B10 (0.44) FFAR1PTPN11PTPROHSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0581272-B1 Tolane derivatives, liquid crystal compositions containing the derivatives and liquid crystal display device using the compositions SEIKO EPSON CORP (JP) 1996-05-08 EP disclosed
US-5356558-A Compatibility, high speed response SEIKO EPSON CORPORATION (JP) 1994-10-18 US disclosed
EP-0581272-A1 Tolane derivatives, liquid crystal compositions containing the derivatives and liquid crystal display device using the compositions SEIKO EPSON CORPORATION (JP) 1994-02-02 EP disclosed