Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28568822 | 0.92 | NPC1 (0.52) | NPC1CYP3A4CYP2C19L3MBTL1TSHR | |
| SCHEMBL8979745 | 0.91 | NPC1 (0.47) | NPC1CYP3A4L3MBTL1TSHRALDH1A1 | |
| SCHEMBL6702666 | 0.88 | TSHR (0.56) | NPC1L3MBTL1TSHRALDH1A1MAPT | |
| SCHEMBL9152703 | 0.87 | NPC1 (0.51) | NPC1TSHRALDH1A1MAPTRAB9A | |
| SCHEMBL15869138 | 0.82 | NPC1 (0.50) | NPC1CYP3A4L3MBTL1TSHRALDH1A1 | |
| SCHEMBL9622282 | 0.81 | NPC1 (0.52) | NPC1TSHRALDH1A1MAPTRAB9A | |
| SCHEMBL3986734 | 0.81 | NPC1 (0.49) | NPC1L3MBTL1TSHRALDH1A1MAPT | |
| SCHEMBL1987313 | 0.81 | TSHR (0.52) | NPC1L3MBTL1TSHRALDH1A1MAPT | |
| SCHEMBL5517752 | 0.81 | NPC1 (0.55) | NPC1L3MBTL1TSHRALDH1A1MAPT | |
| SCHEMBL10390190 | 0.81 | CETP (0.51) | NPC1CYP3A4L3MBTL1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565464-A | Compounds having angiotensine II antagonistic activity | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1996-10-15 | — | — | US | disclosed |
| US-5389659-A | Hypotensive agents | GLAXO GROUP LIMITED (GB) | 1995-02-14 | — | — | US | disclosed |
| WO-1993005025-A1 | C-LINKED PYRAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-03-18 | — | — | WO | disclosed |
| WO-1993003018-A1 | COMPOUNDS HAVING ANGIOTENSINE II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1993-02-18 | — | — | WO | disclosed |
| EP-0446062-A1 | C-Linked pyrazole derivatives | GLAXO GROUP LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |