Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PEPD | P12955 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34169 | 0.98 | PEPD (0.43) | ALDH1A1LMNAPEPDTP53CYP3A4 | |
| SCHEMBL130870 | 0.98 | PEPD (0.43) | ALDH1A1LMNAPEPDTP53CYP3A4 | |
| SCHEMBL598373 | 0.98 | PEPD (0.43) | ALDH1A1LMNAPEPDTP53CYP3A4 | |
| SCHEMBL10578737 | 0.98 | PEPD (0.43) | ALDH1A1LMNAPEPDTP53CYP3A4 | |
| SCHEMBL10739888 | 0.95 | PEPD (0.42) | ALDH1A1LMNAPEPDTP53CYP3A4 | |
| SCHEMBL9663237 | 0.95 | PEPD (0.42) | ALDH1A1LMNAPEPDTP53CYP3A4 | |
| SCHEMBL7031195 | 0.95 | PEPD (0.42) | ALDH1A1LMNAPEPDTP53CYP3A4 | |
| SCHEMBL11660179 | 0.95 | PEPD (0.42) | ALDH1A1LMNAPEPDTP53CYP3A4 | |
| SCHEMBL5525138 | 0.93 | PEPD (0.48) | ALDH1A1LMNAPEPDTP53CYP3A4 | |
| SCHEMBL336245 | 0.93 | PEPD (0.48) | ALDH1A1LMNAPEPDTP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0394192-B1 | Curable mixture based on cycloaliphatic epoxy resins | CIBA GEIGY AG (CH) | 1996-05-29 | — | — | EP | claimed |
| EP-0394192-A2 | Curable mixture based on cycloaliphatic epoxy resins | CIBA-GEIGY AG (CH) | 1990-10-24 | — | — | EP | claimed |