Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 15/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | USP2 | O75604 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538378 | 0.78 | TSHR (0.64) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17486078 | 0.75 | TSHR (0.54) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8535071 | 0.71 | TSHR (0.52) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8537396 | 0.70 | TSHR (0.49) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8981969 | 0.70 | TSHR (0.43) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8537386 | 0.69 | TSHR (0.86) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8534493 | 0.68 | TSHR (0.70) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8537081 | 0.67 | TSHR (0.69) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8538443 | 0.67 | TSHR (0.51) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8535647 | 0.66 | TSHR (0.57) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5489591-A | INHIBITORS OF AROMATASE; TREATING ENDOMETRIOSIS, BREAST CANCER CYSTIC OVARIES | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1996-02-06 | — | — | US | disclosed |