Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 13/20 | 0.94 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.94 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.94 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.91 |
| ▸ | APEX1 | P27695 | 1/20 | 0.91 |
| ▸ | BLM | P54132 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vesamicol SCHEMBL571598 | 0.97 | SLC18A3 (1.00) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 | |
| Vesamicol SCHEMBL4499985 | 0.97 | SLC18A3 (1.00) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 | |
| Vesamicol SCHEMBL4499984 | 0.97 | SLC18A3 (1.00) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 | |
| Vesamicol SCHEMBL12648665 | 0.97 | SLC18A3 (1.00) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 | |
| Vesamicol SCHEMBL29506749 | 0.86 | SLC18A3 (0.79) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL25405320 | 0.81 | SLC18A3 (0.73) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL29187480 | 0.81 | SLC18A3 (0.73) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL29187479 | 0.81 | SLC18A3 (0.73) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL9980685 | 0.81 | SLC18A3 (0.72) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL30595334 | 0.80 | SLC18A3 (1.00) | SLC18A3CYP2D6TSHRSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5554752-A | SPIRO FUSED PIPERIDINES CAPABLE OF BINDING TO A VESAMICOL RECEPTOR AND HAVING ANTICHOLINERGIC PROPERTIES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1996-09-10 | — | — | US | disclosed |
| US-5457207-A | Anticholinergic agents | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1995-10-10 | — | — | US | disclosed |
| WO-1995009631-A1 | SPIROVESAMICOLS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1995-04-13 | — | — | WO | disclosed |