SCHEMBL898464

SCHEMBL898464

C=CC[Si](CC=C)(CC=C)C(C)O[C]=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6406956 0.75
SCHEMBL7927894 0.73
SCHEMBL7399131 0.68
SCHEMBL6721854 0.67
SCHEMBL18918479 0.66
SCHEMBL4779243 0.66
SCHEMBL15520285 0.66
SCHEMBL1490 0.64
SCHEMBL10763379 0.64
SCHEMBL10534579 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1003904-A4 COLOR-ENCODING AND IN-SITU INTERROGATION OF MATRIX-COUPLED CHEMICAL COMPOUNDS BIOARRAY SOLUTIONS LLC (US) 2004-11-03 EP claimed
EP-1003904-A1 COLOR-ENCODING AND IN-SITU INTERROGATION OF MATRIX-COUPLED CHEMICAL COMPOUNDS Bioarray Solutions, LLC (US) 2000-05-31 EP claimed
WO-1998053093-A1 COLOR-ENCODING AND IN-SITU INTERROGATION OF MATRIX-COUPLED CHEMICAL COMPOUNDS BIOARRAY SOLUTIONS LLC (US) 1998-11-26 WO claimed
EP-2268146-B1 INDOLINE ANTI-CANCER AGENTS JOYANT PHARMACEUTICALS INC (US) 2015-08-26 EP disclosed
US-9045401-B2 Methods for treating or ameliorating a melanoma and killing melanoma cells THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-06-02 US disclosed
US-8846734-B2 Diazonamide analogs JOYANT PHARMACEUTICALS, INC. (US) 2014-09-30 US disclosed
US-20140127155-A1 Smac mimetic dimers and trimers useful as anti-cancer agents JOYANT PHARMACEUTICALS, INC (US) 2014-05-08 US disclosed
US-20140100193-A1 Diazonamide Analogs JOYANT PHARMACEUTICALS, INC. (US) 2014-04-10 US disclosed
EP-2699580-A2 DIAZONAMIDE ANALOGS Joyant Pharmaceuticals, Inc. (US) 2014-02-26 EP disclosed
US-8642554-B2 Smac mimetic dimers and trimers useful as anti-cancer agents JOYANT PHARMACEUTICALS, INC. (US) 2014-02-04 US disclosed
US-8592469-B2 Diazonamide analogs JOYANT PHARMACEUTICALS, INC. (US) 2013-11-26 US disclosed
WO-2008154441-A1 METHODS FOR PREPARING DIAZONAMIDES JOYANT PHARMACEUTICALS, INC. (US) 2008-12-18 WO disclosed
WO-2008147713-A1 WNT SIGNALING INHIBITORS, AND METHODS FOR MAKING AND USING THEM THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-12-04 WO disclosed
EP-1996184-A2 SMALL MOLECULE APOPTOSIS PROMOTERS Joyant Pharmaceuticals, Inc. (US) 2008-12-03 EP disclosed
WO-2008144747-A2 LIPOPROTEINS, LIPOPEPTIDES AND ANALOGS, AND METHODS FOR MAKING AND USING THEM THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-11-27 WO disclosed
WO-2008128121-A1 SMAC MIMETIC DIMERS AND TRIMERS USEFUL AS ANTI-CANCER AGENTS JOYANT PHARMACEUTICALS, INC. (US) 2008-10-23 WO disclosed
US-20080051389-A1 Small molecule apoptosis promoters JOYANT PHARMACEUTICALS, INC. 2008-02-28 US disclosed
WO-2007136921-A2 SMALL MOLECULE APOPTOSIS PROMOTERS JOYANT PHARMACEUTICALS, INC. (US) 2007-11-29 WO disclosed
WO-2007109620-A2 MACROCYCLIC PEPTIDES AND METHODS FOR MAKING AND USING THEM SAN DIEGO STATE UNIVERSITY FOUNDATION (US) 2007-09-27 WO disclosed
WO-2004024777-A1 HYDROXYALKYL STARCH DERIVATIVES FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2004-03-25 WO disclosed