Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.74 |
| ▸ | HTR1B | P28222 | 5/20 | 0.74 |
| ▸ | HTR2A | P28223 | 4/20 | 0.74 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | HTR1E | P28566 | 1/20 | 0.60 |
| ▸ | HTR1F | P30939 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805150 | 0.93 | HTR1D (0.77) | HTR1DHTR1BHTR2ARAB9ANPC1 | |
| SCHEMBL8985970 | 0.87 | HTR1D (0.92) | HTR1DHTR1BHTR2ARAB9ANPC1 | |
| SCHEMBL8402123 | 0.86 | HTR1D (0.65) | HTR1DHTR1BHTR2AHTR1AHTR2C | |
| SCHEMBL7803371 | 0.85 | HTR1D (1.00) | HTR1DHTR1BHTR2ARAB9ANPC1 | |
| SCHEMBL8985968 | 0.83 | MCHR1 (0.62) | HTR1DHTR1BHTR2ARAB9ANPC1 | |
| SCHEMBL9332850 | 0.83 | HTR1D (0.71) | HTR1DHTR1BHTR2ARAB9AHTR1A | |
| SCHEMBL9332899 | 0.82 | HTR1D (0.59) | HTR1DHTR1BHTR2ARAB9ANPC1 | |
| SCHEMBL8305478 | 0.82 | HTR1D (0.70) | HTR1DHTR1BHTR2ARAB9ANPC1 | |
| SCHEMBL8705195 | 0.82 | HTR1D (0.70) | HTR1DHTR1BHTR2ARAB9ANPC1 | |
| SCHEMBL8704883 | 0.82 | HTR1D (0.70) | HTR1DHTR1BHTR2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716656-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-19 | — | — | EP | claimed |
| WO-1995006644-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-09 | — | — | WO | claimed |
| EP-0716656-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-19 | — | — | EP | disclosed |
| WO-1995006644-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-09 | — | — | WO | disclosed |