Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831245 | 0.86 | KDM4E (0.52) | IKBKBNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9831294 | 0.86 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL821117 | 0.86 | IKBKB (0.46) | IKBKBNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6377222 | 0.86 | KDM4E (0.51) | IKBKBNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13361730 | 0.84 | IKBKB (0.46) | IKBKBNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5639362 | 0.83 | TARBP2 (0.54) | IKBKBNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9830290 | 0.83 | KDM4E (0.41) | IKBKBRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4467452 | 0.82 | PPARD (0.58) | IKBKBNPC1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL8989102 | 0.82 | IKBKB (0.45) | IKBKBNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13455121 | 0.82 | IKBKB (0.45) | IKBKBNPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |