Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9069759 | 0.90 | HDAC3 (0.62) | NPC1RAB9AHDAC3NCOR2HTT | |
| SCHEMBL9191954 | 0.90 | HDAC3 (0.66) | NPC1RAB9AHDAC3NCOR2HTT | |
| SCHEMBL8638370 | 0.89 | NPC1 (0.59) | NPC1RAB9AHDAC3NCOR2 | |
| SCHEMBL7981993 | 0.89 | HDAC3 (0.64) | NPC1RAB9AHDAC3NCOR2 | |
| SCHEMBL1377409 | 0.88 | HDAC3 (0.68) | NPC1RAB9AHDAC3NCOR2HTT | |
| SCHEMBL1374654 | 0.88 | HDAC3 (0.68) | NPC1RAB9AHDAC3NCOR2HTT | |
| SCHEMBL9191952 | 0.87 | HDAC3 (0.71) | NPC1RAB9AHDAC3NCOR2 | |
| SCHEMBL28840174 | 0.86 | NPC1 (0.60) | NPC1RAB9AHDAC3NCOR2 | |
| SCHEMBL23080107 | 0.86 | NPC1 (0.59) | NPC1RAB9AHDAC3NCOR2CASP1 | |
| SCHEMBL6763786 | 0.86 | HDAC3 (0.74) | NPC1RAB9AHDAC3NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5492839-A | RADIOIMMUNOASSAY; STIMULATES PRODUCTION OF ANTIBODIES WHICH BIND SPECIFICALLY TO RYANODINE; LABELED AFFINITY REAGENT | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1996-02-20 | — | — | US | disclosed |
| US-4642315-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4587234-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1986-05-06 | — | — | US | disclosed |
| US-4499079-A | ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-02-12 | — | — | US | disclosed |