SCHEMBL8991925

SCHEMBL8991925

C[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CCC(c2ccccc2)CC1

nearest known ligand 0.50

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.50
TACR2 P21452 3/20 0.48
TACR3 P29371 3/20 0.48
CCR5 P51681 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19440990 1.00 TACR1 (0.50) TACR1TACR2TACR3CCR5
Iodide SCHEMBL8840263 0.99 TACR1 (0.49) TACR1TACR2TACR3CCR5
SCHEMBL15678895 0.90 TACR1 (0.52) TACR1TACR2TACR3CCR5
SCHEMBL8991959 0.85 TACR1 (0.63) TACR1TACR2TACR3CCR5
SCHEMBL22901986 0.85 TACR1 (0.63) TACR1TACR2TACR3CCR5
Hydrochloric Acid SCHEMBL8840357 0.84 TACR1 (0.62) TACR1TACR2TACR3CCR5
SCHEMBL8991942 0.83 TACR1 (0.53) TACR1TACR2TACR3
Water SCHEMBL8840295 0.81 TACR1 (0.52) TACR1TACR2TACR3CCR5
SCHEMBL8992082 0.80 TACR1 (0.52) TACR1TACR2TACR3CCR5
Hydrochloric Acid SCHEMBL8840285 0.79 TACR1 (0.51) TACR1TACR2TACR3CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0723959-A1 Heterocyclic compounds as tachykinin receptor antagonists, process for their preparation and pharmaceuticals containing them SANOFI (FR) 1996-07-31 EP disclosed