Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR1 | P30872 | 1/20 | 0.54 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.54 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.54 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.54 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 9/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.48 |
| ▸ | CDC25B | P30305 | 6/20 | 0.46 |
| ▸ | GJB2 | P29033 | 1/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992112 | 0.98 | SSTR1 (0.56) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL8992144 | 0.92 | SSTR1 (0.60) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL8992149 | 0.92 | SSTR1 (0.60) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL8992062 | 0.91 | SSTR1 (0.56) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL8992067 | 0.91 | SSTR1 (0.56) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL6667240 | 0.88 | SSTR1 (0.56) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL18671706 | 0.88 | SSTR1 (0.56) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL16560345 | 0.86 | SSTR1 (0.52) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL3752664 | 0.85 | SSTR1 (0.70) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL6872203 | 0.85 | SSTR1 (0.70) | SSTR1SSTR2SSTR4SSTR3SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5504078-A | α-glucosidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-04-02 | — | — | US | disclosed |
| EP-0532668-B1 | NOVEL ALPHA-GLUCOSIDASE INHIBITORS | MERRELL DOW PHARMA (US) | 1995-11-15 | — | — | EP | disclosed |
| EP-0345104-B1 | Novel Alpha-glucosidase inhibitors | MERRELL DOW PHARMA (US) | 1995-11-02 | — | — | EP | disclosed |
| EP-0422975-B1 | Alpha-glucosidase inhibitors | MERRELL DOW PHARMA (US) | 1994-07-27 | — | — | EP | disclosed |
| US-5157116-A | Antidiabetic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-20 | — | — | US | disclosed |
| US-5097023-A | α-glucosidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0422975-A1 | Alpha-glucosidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-17 | — | — | EP | disclosed |
| EP-0422307-A1 | Novel alpha-glucosidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-17 | — | — | EP | disclosed |
| EP-0389723-A1 | Novel alpha-glucosidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-10-03 | — | — | EP | disclosed |
| EP-0390674-A1 | Novel alpha-glucosidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-10-03 | — | — | EP | disclosed |
| EP-0344383-A1 | Novel alpha-Glucosidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-12-06 | — | — | EP | disclosed |
| EP-0345104-A2 | Novel Alpha-glucosidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-12-06 | — | — | EP | disclosed |