SCHEMBL8993778

SCHEMBL8993778

CCOC(=O)C(Cc1ccc(C(=N)N)cc1)N1CCC(NS(=O)(=O)c2cc(OC)c3cc(OC)ccc3c2)C1=O

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
F10 P00742 18/20 0.56
F2 P00734 7/20 0.50
F9 P00740 1/20 0.50
PRSS1 P07477 4/20 0.49
PLG P00747 2/20 0.49
PROC P04070 2/20 0.49
PLAT P00750 1/20 0.48
PRSS2 P07478 2/20 0.47
PRSS3 P35030 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8993786 0.96 F10 (0.53) F10F2F9PRSS1PLG
SCHEMBL8993695 0.93 F10 (0.59) F10F2PRSS1PLGPROC
SCHEMBL8993789 0.92 F10 (0.51) F10F2F9PRSS1PLG
SCHEMBL8993718 0.91 F10 (0.67) F10F2PRSS1PLGPROC
SCHEMBL8993681 0.90 F10 (0.69) F10F2PRSS1PLGPROC
SCHEMBL8993840 0.89 F10 (0.59) F10F2F9PRSS1PLG
SCHEMBL8993824 0.89 F10 (0.55) F10F2PRSS1PLGPROC
SCHEMBL8993727 0.89 F10 (0.55) F10F2PRSS1PLGPROC
SCHEMBL8993682 0.88 F2 (0.51) F10F2F9PRSS1PLG
SCHEMBL8993733 0.87 F10 (0.63) F10F2PRSS1PLGPROC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5489583-A FOR TREATING OR PREVENTING THROMBOSIS BASF AKTIENGESELLSCHAFT (DE) 1996-02-06 US disclosed