Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29458957 | 0.90 | — | — | |
| SCHEMBL5489439 | 0.90 | TAAR1 (0.54) | CHRM2TAAR1HPGDALDH1A1PTGS2 | |
| SCHEMBL40576 | 0.90 | — | — | |
| Dimethylamine SCHEMBL4576084 | 0.88 | TAAR1 (0.48) | CHRM2TAAR1HPGDALDH1A1PTGS2 | |
| Ammonia Solution, Strong SCHEMBL9453011 | 0.87 | TAAR1 (0.52) | CHRM2TAAR1HPGDALDH1A1PTGS2 | |
| O-Xylene SCHEMBL9356149 | 0.87 | TSHR (0.56) | CHRM2TAAR1HPGDALDH1A1PTGS2 | |
| SCHEMBL31498537 | 0.87 | TAAR1 (0.52) | CHRM2TAAR1HPGDALDH1A1PTGS2 | |
| SCHEMBL5157331 | 0.87 | TAAR1 (0.52) | CHRM2TAAR1HPGDALDH1A1PTGS2 | |
| Ammonia Solution, Strong SCHEMBL5005672 | 0.87 | TAAR1 (0.52) | CHRM2TAAR1HPGDALDH1A1PTGS2 | |
| Hydrogen Sulfide SCHEMBL28235130 | 0.87 | TAAR1 (0.52) | CHRM2TAAR1HPGDALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538826-A | CONTACT CHARGING STEPS FOR ELECTROPHOTOGRAPHIC PHOTOSENSITIVE SURFACES WITH BISPHENOL Z POLYCARBONATES AND IMAGES | CANON KABUSHIKI KAISHA (JP) | 1996-07-23 | — | — | US | disclosed |
| EP-0643339-A1 | Electrophotographic image forming method, apparatus and device unit | CANON KABUSHIKI KAISHA (JP) | 1995-03-15 | — | — | EP | disclosed |