Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 12/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15315064 | 0.95 | TSHR (0.52) | TSHRALDH1A1CYP3A4FOLH1HPGD | |
| SCHEMBL29507133 | 0.94 | TSHR (0.55) | TSHRALDH1A1CYP3A4FOLH1HPGD | |
| SCHEMBL28108439 | 0.89 | TSHR (0.52) | TSHRALDH1A1CYP3A4FOLH1HPGD | |
| SCHEMBL29448443 | 0.86 | TSHR (0.56) | TSHRALDH1A1CYP3A4FOLH1HPGD | |
| SCHEMBL2534122 | 0.86 | TSHR (0.47) | TSHRALDH1A1CYP3A4FOLH1HPGD | |
| SCHEMBL29448450 | 0.84 | TSHR (0.64) | TSHRALDH1A1CYP3A4HPGDTP53 | |
| SCHEMBL27887847 | 0.83 | TSHR (0.62) | TSHRALDH1A1CYP3A4HPGD | |
| SCHEMBL8665338 | 0.83 | TSHR (0.56) | TSHRALDH1A1CYP3A4HPGDTP53 | |
| SCHEMBL30004436 | 0.82 | TSHR (0.51) | TSHRALDH1A1CYP3A4FOLH1HPGD | |
| SCHEMBL19133682 | 0.81 | TSHR (0.53) | TSHRALDH1A1CYP3A4FOLH1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462670-B1 | Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to caboxylated particles & a kit containing same | JOHNSON & JOHNSON CLIN DIAG (US) | 1996-08-21 | — | — | EP | claimed |
| EP-0462644-B1 | Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use | JOHNSON & JOHNSON CLIN DIAG (US) | 1995-10-18 | — | — | EP | claimed |