SCHEMBL8995728

SCHEMBL8995728

Cc1ccc(C(C)Nc2c(Nc3ccc(C#N)cc3)c(=O)c2=O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 10/20 0.51
PLK1 P53350 6/20 0.50
ROCK1 Q13464 3/20 0.50
AURKB Q96GD4 2/20 0.50
ROCK2 O75116 2/20 0.50
CHEK2 O96017 2/20 0.50
GSK3A P49840 2/20 0.50
GSK3B P49841 2/20 0.50
PRKX P51817 2/20 0.50
CSNK1G2 P78368 2/20 0.50
CDC42BPA Q5VT25 2/20 0.50
CLK4 Q9HAZ1 2/20 0.50
STK17A Q9UEE5 2/20 0.50
CSNK1G3 Q9Y6M4 2/20 0.50
CSNK1G1 Q9HCP0 2/20 0.50
DCLK1 O15075 1/20 0.50
IRAK1 P51617 1/20 0.50
NEK4 P51957 1/20 0.50
BRSK1 Q8TDC3 1/20 0.50
CYP3A4 P08684 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8995725 1.00 MAPKAPK2 (0.51) MAPKAPK2PLK1ROCK1AURKBROCK2
SCHEMBL8870870 0.88 MAPKAPK2 (0.65) MAPKAPK2PLK1ROCK1AURKBROCK2
SCHEMBL9146091 0.88 MAPKAPK2 (0.65) MAPKAPK2PLK1ROCK1AURKBROCK2
SCHEMBL8871512 0.88 MAPKAPK2 (0.65) MAPKAPK2PLK1ROCK1AURKBROCK2
SCHEMBL8872684 0.86 MAPKAPK2 (0.48) MAPKAPK2PLK1ROCK1AURKBROCK2
SCHEMBL8872677 0.86 MAPKAPK2 (0.48) MAPKAPK2PLK1ROCK1AURKBROCK2
SCHEMBL4538414 0.86 MAPKAPK2 (0.70) MAPKAPK2PLK1ROCK1AURKBROCK2
SCHEMBL8870227 0.84 CXCR2 (0.51) MAPKAPK2PLK1ROCK1AURKBROCK2
SCHEMBL8870223 0.84 CXCR2 (0.51) MAPKAPK2PLK1ROCK1AURKBROCK2
SCHEMBL8995730 0.83 HDAC1 (0.50) MAPKAPK2PLK1ROCK1AURKBROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5466712-A Smooth muscle relaxants AMERICAN HOME PRODUCTS CORPORATION (US) 1995-11-14 US claimed
US-5532245-A TO REDUCE SMOOTH MUSCLE CONTRACTIONS; TREATMENT FOR URINARY INCONTINENCE, IRITABLE BOWEL SYNDROME AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-02 US disclosed