Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.73 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | XDH | P47989 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996776 | 0.95 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10758080 | 0.88 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10757789 | 0.86 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL8479743 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10762505 | 0.85 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL8996786 | 0.84 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10761953 | 0.83 | PDE4B (0.79) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10757223 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10759373 | 0.81 | PDE4B (0.71) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10761260 | 0.81 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593567-B1 | USE OF SUBSTITUTED PYRIDAZINES AGAINST DERMATOSIS | BYK GULDEN LOMBERG CHEM FAB (DE) | 1996-08-28 | — | — | EP | claimed |
| EP-0593567-A1 | USE OF SUBSTITUTED PYRIDAZINES AGAINST DERMATOSIS. | BYK GULDEN LOMBERG CHEM FAB (DE) | 1994-04-27 | — | — | EP | claimed |
| WO-1993000903-A1 | USE OF SUBSTITUTED PYRIDAZINES AGAINST DERMATOSIS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-01-21 | — | — | WO | claimed |
| EP-0523513-A1 | Use of substituted pyridazines for the treatment of dermatoses | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1993-01-20 | — | — | EP | claimed |
| EP-0125636-B1 | PYRIDAZINONES, THEIR PREPARATION AND USE, MEDICINES CONTAINING THESE PYRIDAZINONES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1987-04-01 | — | — | EP | claimed |
| WO-1984004521-A1 | PYRIDAZINONES, THEIR PREPARATION AND USE, AND MEDICAMENTS CONTAINING PYRIDAZINONES | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-22 | — | — | WO | claimed |
| EP-0125636-A1 | Pyridazinones, their preparation and use, medicines containing these pyridazinones | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1984-11-21 | — | — | EP | claimed |
| EP-0593567-B1 | USE OF SUBSTITUTED PYRIDAZINES AGAINST DERMATOSIS | BYK GULDEN LOMBERG CHEM FAB (DE) | 1996-08-28 | — | — | EP | disclosed |
| EP-0523513-A1 | Use of substituted pyridazines for the treatment of dermatoses | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1993-01-20 | — | — | EP | disclosed |
| US-4707481-A | Pyridazinones, their preparation and use, and bronchospasmolytic medicaments containing pyridazinones | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1987-11-17 | — | — | US | disclosed |
| EP-0125636-B1 | PYRIDAZINONES, THEIR PREPARATION AND USE, MEDICINES CONTAINING THESE PYRIDAZINONES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| WO-1984004521-A1 | PYRIDAZINONES, THEIR PREPARATION AND USE, AND MEDICAMENTS CONTAINING PYRIDAZINONES | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-22 | — | — | WO | disclosed |
| EP-0125636-A1 | Pyridazinones, their preparation and use, medicines containing these pyridazinones | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1984-11-21 | — | — | EP | disclosed |