Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 13/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 9/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HSD3B1 | P14060 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL916826 | 0.83 | SRD5A1 (0.45) | SRD5A1SRD5A2 | |
| SCHEMBL8002628 | 0.82 | SRD5A1 (0.37) | SRD5A1SRD5A2 | |
| SCHEMBL8002631 | 0.82 | SRD5A1 (0.37) | SRD5A1SRD5A2 | |
| SCHEMBL8003663 | 0.82 | SRD5A1 (0.37) | SRD5A1SRD5A2 | |
| SCHEMBL8003658 | 0.82 | SRD5A1 (0.37) | SRD5A1SRD5A2 | |
| SCHEMBL8016968 | 0.81 | SRD5A1 (0.58) | SRD5A1SRD5A2ABCC4ABCB11LMNA | |
| SCHEMBL8096297 | 0.79 | SRD5A1 (0.55) | SRD5A1SRD5A2ABCC4ABCB11LMNA | |
| SCHEMBL8096293 | 0.79 | SRD5A1 (0.55) | SRD5A1SRD5A2ABCC4ABCB11LMNA | |
| SCHEMBL4265542 | 0.79 | SRD5A1 (0.66) | SRD5A1SRD5A2ABCC4ABCB11LMNA | |
| SCHEMBL4278336 | 0.79 | SRD5A1 (0.66) | SRD5A1SRD5A2ABCC4ABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724592-A1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO. INC. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011254-A1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO., INC. (US) | 1995-04-27 | — | — | WO | disclosed |