Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL8998230

N.O=C(O)C(CCO)CCO

nearest known ligand 0.52

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Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.52
CHRM1 P11229 1/20 0.52
AKR1A1 P14550 1/20 0.52
CHRM3 P20309 1/20 0.52
HTR2A P28223 1/20 0.52
HTR2C P28335 1/20 0.52
ADRA1A P35348 1/20 0.52
HRH1 P35367 1/20 0.52
DRD3 P35462 1/20 0.52
SLC6A3 Q01959 1/20 0.52
HDAC1 Q13547 1/20 0.52
HDAC2 Q92769 1/20 0.52
FOLH1 Q04609 10/20 0.42
SLC1A1 P43005 1/20 0.39
CA2 P00918 1/20 0.39
MAPK1 P28482 1/20 0.39
OR51E2 Q9H255 1/20 0.36
CPB2 Q96IY4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3893901 0.97 CHRM1 (0.55) TDP1CHRM1AKR1A1CHRM3HTR2A
Ammonia Solution, Strong SCHEMBL10355457 0.88 SLC1A1 (0.46) TDP1CHRM1AKR1A1CHRM3HTR2A
SCHEMBL3892318 0.86 CHRM1 (0.52) TDP1CHRM1AKR1A1CHRM3HTR2A
SCHEMBL36647 0.85
SCHEMBL928641 0.84 FOLH1 (0.64) FOLH1
SCHEMBL14764160 0.84 CHRM1 (0.50) TDP1CHRM1AKR1A1CHRM3HTR2A
SCHEMBL2230798 0.84 CHRM1 (0.80) TDP1CHRM1AKR1A1CHRM3HTR2A
SCHEMBL29100382 0.84 GABRR1 (0.46) TDP1CHRM1AKR1A1CHRM3HTR2A
SCHEMBL16061831 0.84 CHRM1 (0.80) TDP1CHRM1AKR1A1CHRM3HTR2A
SCHEMBL6557049 0.82 SLC1A1 (0.46) TDP1CHRM1AKR1A1CHRM3HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0725636-A1 HYDROXYL IONS AS UNIQUE THERAPEUTIC AGENTS AND COMPOUNDS THAT MODULATE THESE IONS, COMPOSITIONS EMPLOYING THESE AGENTS, THERAPEUTIC METHODS FOR USING SUCH AGENTS AND PROCESSES FOR PREPARING THEM FHJ SCIENTIFIC, INC. (US) 1996-08-14 EP disclosed
WO-1995010272-A1 HYDROXYL IONS AS UNIQUE THERAPEUTIC AGENTS AND COMPOUNDS THAT MODULATE THESE IONS, COMPOSITIONS EMPLOYING THESE AGENTS, THERAPEUTIC METHODS FOR USING SUCH AGENTS AND PROCESSES FOR PREPARING THEM FHJ SCIENTIFIC, INC. (US) 1995-04-20 WO disclosed