Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 6/20 | 0.66 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9227940 | 1.00 | PREP (0.66) | PREPKLK7KLK5ACE2CTRB1 | |
| SCHEMBL8998471 | 1.00 | PREP (0.66) | PREPKLK7KLK5ACE2CTRB1 | |
| SCHEMBL8998537 | 0.85 | PREP (0.74) | PREPKLK7KLK5ACE2CTRB1 | |
| SCHEMBL8998528 | 0.85 | PREP (0.74) | PREPKLK7KLK5ACE2CTRB1 | |
| SCHEMBL8998533 | 0.85 | PREP (0.74) | PREPKLK7KLK5ACE2CTRB1 | |
| SCHEMBL8998490 | 0.85 | PREP (0.59) | PREPKLK7KLK5CTRB1NPSR1 | |
| SCHEMBL8998505 | 0.85 | PREP (0.59) | PREPKLK7KLK5CTRB1NPSR1 | |
| SCHEMBL8998409 | 0.80 | PREP (0.72) | PREPKLK7KLK5CTRB1NPSR1 | |
| SCHEMBL8998388 | 0.80 | PREP (0.72) | PREPKLK7KLK5CTRB1NPSR1 | |
| SCHEMBL8998396 | 0.80 | PREP (0.72) | PREPKLK7KLK5CTRB1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536737-A | Compound having prolyl endopeptidase inhibitory activity and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 1996-07-16 | — | — | US | disclosed |
| EP-0670309-A1 | COMPOUND WITH PROLYL ENDOPEPTIDASE INHIBITOR ACTIVITY AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 1995-09-06 | — | — | EP | disclosed |