SCHEMBL8999427

SCHEMBL8999427

NC(=O)C1CC2OC2CC1C(=O)Nc1ccccc1NC(=O)C1CC2OC2CC1C(N)=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.42
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 5/20 0.40
MAPT P10636 1/20 0.40
F13A1 P00488 1/20 0.40
TGM2 P21980 1/20 0.40
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
TSHR P16473 2/20 0.38
POLB P06746 1/20 0.38
CYP2C19 P33261 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
TYK2 P29597 1/20 0.37
PARP1 P09874 1/20 0.37
PARP10 Q53GL7 1/20 0.37
GAA P10253 1/20 0.37
SIRT1 Q96EB6 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL867250 0.82 PARP1 (0.53) LMNAALDH1A1KDM4EF13A1TGM2
SCHEMBL27917664 0.75 EPHX1 (0.36) LMNAKDM4ETSHR
SCHEMBL29420722 0.75 KDM4E (0.66) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL961995 0.75 KDM4E (0.66) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL960402 0.73 POLB (0.59) LMNAALDH1A1KDM4EMAPTF13A1
SCHEMBL3928666 0.66 GAA (0.67) LMNAALDH1A1KDM4EMAPTMEN1
SCHEMBL29840068 0.66 GAA (0.67) LMNAALDH1A1KDM4EMAPTMEN1
SCHEMBL30932514 0.64 TP53 (0.48) LMNAALDH1A1KDM4ETSHRPOLB
SCHEMBL17761768 0.64 KDM4E (0.60) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL23387345 0.64 POLB (0.61) LMNAALDH1A1KDM4EMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0572651-B1 NITROGENOUS MULTIACRYLIC MONOMERS, PREPARATION AND APPLICATION THEREOF IN PRODUCING NOVEL POLYMERS CRAY VALLEY SA (FR) 1996-08-21 EP disclosed
EP-0572651-A1 NITROGENOUS MULTIACRYLIC MONOMERS, PREPARATION AND APPLICATION THEREOF IN PRODUCING NOVEL POLYMERS. CRAY VALLEY SA (FR) 1993-12-08 EP disclosed
WO-1993013050-A1 NITROGENOUS MULTIACRYLIC MONOMERS, PREPARATION AND APPLICATION THEREOF IN PRODUCING NOVEL POLYMERS CRAY VALLEY S.A. (FR) 1993-07-08 WO disclosed