Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 7/20 | 0.43 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.43 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000749 | 0.92 | SOAT1 (0.42) | SOAT1SOAT2ACAT1MAPTTRPV1 | |
| SCHEMBL9000680 | 0.90 | SOAT1 (0.45) | SOAT1SOAT2ACAT1GPR84SMN1; SMN2 | |
| SCHEMBL9000769 | 0.89 | SOAT1 (0.44) | SOAT1SOAT2ACAT1GPR84MAPT | |
| SCHEMBL9000790 | 0.89 | SOAT1 (0.44) | SOAT1SOAT2ACAT1MAPTMEN1 | |
| SCHEMBL9000516 | 0.89 | SOAT1 (0.55) | SOAT1SOAT2ACAT1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9000915 | 0.88 | SOAT1 (0.44) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9000916 | 0.88 | SOAT1 (0.49) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9000962 | 0.88 | SOAT1 (0.43) | SOAT1SOAT2ACAT1ALDH1A1 | |
| SCHEMBL9000890 | 0.88 | SOAT1 (0.43) | SOAT1SOAT2ACAT1MAPTSMN1; SMN2 | |
| SCHEMBL9000356 | 0.86 | SOAT1 (0.42) | SOAT1SOAT2ACAT1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |