Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | DRD1 | P21728 | 2/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL900566 | 1.00 | CHRM2 (0.63) | CHRM2CHRM1ADRA2ADRD1SLC6A2 | |
| SCHEMBL2722328 | 0.93 | CHRM1 (0.53) | CHRM2CHRM1ADRA2ADRD1SLC6A2 | |
| SCHEMBL2722079 | 0.92 | CHRM2 (0.52) | CHRM2CHRM1ADRA2ADRD1SLC6A2 | |
| SCHEMBL2720633 | 0.91 | CHRM1 (0.51) | CHRM2CHRM1ADRA2ADRD1SLC6A2 | |
| SCHEMBL2719906 | 0.91 | DRD3 (0.51) | CHRM2CHRM1ADRA2ADRD1SLC6A2 | |
| SCHEMBL900508 | 0.90 | CHRM2 (0.51) | CHRM2CHRM1ADRA2ADRD1SLC6A2 | |
| SCHEMBL900368 | 0.90 | MAPK1 (0.55) | CHRM2CHRM1ADRA2ADRD1SLC6A2 | |
| SCHEMBL20503142 | 0.89 | CHRM2 (0.49) | CHRM2CHRM1ADRA2ADRD1SLC6A2 | |
| SCHEMBL2720681 | 0.89 | CHRM2 (0.49) | CHRM2CHRM1ADRA2ADRD1SLC6A2 | |
| SCHEMBL900072 | 0.89 | HRH3 (0.49) | CHRM2CHRM1ADRA2ADRD1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621916-A1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET (FR) | 2013-08-07 | — | — | EP | disclosed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | disclosed |
| WO-2012041860-A1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET (FR) | 2012-04-05 | — | — | WO | disclosed |