SCHEMBL9001383

SCHEMBL9001383

CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 16/20 1.00
KMT2A Q03164 2/20 0.73
KDM4E B2RXH2 1/20 0.73
MEN1 O00255 1/20 0.73
ALDH1A1 P00352 1/20 0.73
LMNA P02545 1/20 0.73
TP53 P04637 1/20 0.73
CYP1A2 P05177 1/20 0.73
POLB P06746 1/20 0.73
CYP3A4 P08684 1/20 0.73
CYP2D6 P10635 1/20 0.73
MAPT P10636 1/20 0.73
CYP2C9 P11712 1/20 0.73
NFKB1 P19838 1/20 0.73
APEX1 P27695 1/20 0.73
CYP2C19 P33261 1/20 0.73
THPO P40225 1/20 0.73
BLM P54132 1/20 0.73
NPSR1 Q6W5P4 1/20 0.73
ACE P12821 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9358926 0.89 TACR1 (0.80) TACR1KMT2AKDM4EMEN1ALDH1A1
SCHEMBL8915625 0.89 TACR1 (0.80) TACR1KMT2AKDM4EMEN1ALDH1A1
SCHEMBL8915620 0.89 TACR1 (0.80) TACR1KMT2AKDM4EMEN1ALDH1A1
SCHEMBL9001371 0.89 TACR1 (0.80) TACR1KMT2AKDM4EMEN1ALDH1A1
Hydrochloric Acid SCHEMBL9315503 0.88 TACR1 (0.79) TACR1KMT2AKDM4EMEN1ALDH1A1
SCHEMBL9362774 0.88 TACR1 (0.79) TACR1KMT2AKDM4EMEN1ALDH1A1
SCHEMBL8883543 0.88 TACR1 (0.79) TACR1KMT2AKDM4EMEN1ALDH1A1
SCHEMBL8917025 0.88 TACR1 (0.78) TACR1KMT2AKDM4EMEN1ALDH1A1
SCHEMBL8917033 0.88 TACR1 (0.78) TACR1KMT2AKDM4EMEN1ALDH1A1
Hydrochloric Acid SCHEMBL9358600 0.87 TACR1 (0.77) TACR1KMT2AKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0629196-A1 HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM MERCK SHARP & DOHME LTD. (GB) 1994-12-21 EP claimed
WO-1993018023-A1 HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM MERCK SHARP & DOHME LIMITED (GB) 1993-09-16 WO claimed
US-5514718-A AMINO COMPOUNDS WITH ALKOXY, HYDROXY, KETONE OR OXIME GROUPS FOR PSYCHOLOGICAL DISORDERS OR TACHYKININ ANTAGONIST MERCK, SHARP & DOHME LIMITED (GB) 1996-05-07 US disclosed
EP-0629196-A1 HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM MERCK SHARP & DOHME LTD. (GB) 1994-12-21 EP disclosed
US-5328927-A Tachykinin antagonists MERCK SHARPE & DOHME, LTD. (GB) 1994-07-12 US disclosed
WO-1993018023-A1 HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM MERCK SHARP & DOHME LIMITED (GB) 1993-09-16 WO disclosed