Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.61 |
| ▸ | RORB | Q92753 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 6/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TOP1 | P11387 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10768030 | 0.90 | PDE4D (0.60) | PDE4DPDE4APDE4CPDE4BKMT2A | |
| SCHEMBL7273341 | 0.90 | PDE4D (0.60) | PDE4DPDE4APDE4CPDE4BKMT2A | |
| SCHEMBL27993567 | 0.89 | KMT2A (0.60) | PDE4DPDE4APDE4CPDE4BKMT2A | |
| SCHEMBL6433855 | 0.85 | PDE4D (0.55) | PDE4DPDE4APDE4CPDE4BKMT2A | |
| Bromide SCHEMBL7238592 | 0.81 | PDE4D (0.63) | PDE4DPDE4APDE4CPDE4BKMT2A | |
| SCHEMBL7236603 | 0.80 | PDE4D (0.61) | PDE4DPDE4APDE4CPDE4BKMT2A | |
| SCHEMBL28144687 | 0.79 | PDE4D (0.64) | PDE4DPDE4APDE4CPDE4BKMT2A | |
| SCHEMBL28145745 | 0.79 | PDE4D (0.64) | PDE4DPDE4APDE4CPDE4BMAPT | |
| SCHEMBL27364256 | 0.79 | PDE4D (0.64) | PDE4DPDE4APDE4CPDE4BKMT2A | |
| SCHEMBL7230945 | 0.79 | PDE4D (0.64) | PDE4DPDE4APDE4CPDE4BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482948-A | Pyridyl derivatives and pharmaceutical compositions comprising these compounds | DR. KARL THOMAE GMBH (DE) | 1996-01-09 | — | — | US | disclosed |
| US-5286736-A | Thromboxane antagonists and thromboxane synthetase inhibitors | DR. KARL THOMAE GMBH (DE) | 1994-02-15 | — | — | US | disclosed |