Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890619 | 0.81 | HTR2A (0.50) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL22781503 | 0.81 | CHRNB4 (0.44) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL8890510 | 0.79 | — | — | |
| SCHEMBL30317790 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL23923444 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL23940041 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL23923588 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL30317799 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL23923443 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL8331359 | 0.77 | HTR2A (0.43) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5457120-A | Antisecretory and antiserotonine agents | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |