SCHEMBL9006027

SCHEMBL9006027

CC(C)(C)ON(C=O)C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.67
CACNA1F O60840 4/20 0.53
CACNA1D Q01668 4/20 0.53
CACNA1S Q13698 4/20 0.53
CACNA1C Q13936 4/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8936895 0.87 TACR1 (0.59) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911717 0.81 TACR1 (1.00) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8965767 0.79 TACR1 (0.67) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8936893 0.78 TACR1 (0.69) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8936861 0.77 TACR1 (0.67) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8826999 0.77 TACR1 (0.73) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8827247 0.77 TACR1 (0.73) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8826988 0.77 TACR1 (0.73) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9392876 0.76 TACR1 (0.69) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9392869 0.76 TACR1 (0.69) TACR1CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5554633-A ANTIINFLAMMATORY, ANTIARTHRITIC, AND ANALGESIC AGENTS; MIGRAINE MERCK, SHARP & DOHME, LTD. (GB) 1996-09-10 US disclosed
WO-1994003429-A1 SUBSTITUTED AMINES AS TACHYKININ RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 1994-02-17 WO disclosed