SCHEMBL9006797

SCHEMBL9006797

Oc1ccc2c(c1)C[C@H](NC[C@@H](O)c1cccc(Cl)c1)CC2

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADRB3 P13945 12/20 0.70
ADRB1 P08588 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8829602 1.00 ADRB3 (0.70) ADRB3ADRB1
SCHEMBL3697691 1.00 ADRB3 (0.70) ADRB3ADRB1
SCHEMBL9483243 1.00 ADRB3 (0.70) ADRB3ADRB1
SCHEMBL6133378 1.00 ADRB3 (0.70) ADRB3ADRB1
SCHEMBL5188566 1.00 ADRB3 (0.70) ADRB3ADRB1
SCHEMBL9006647 1.00 ADRB3 (0.70) ADRB3ADRB1
Hydrochloric Acid SCHEMBL9317513 0.99 ADRB3 (0.69) ADRB3ADRB1
Hydrochloric Acid SCHEMBL10799438 0.99 ADRB3 (0.69) ADRB3ADRB1
Bromide SCHEMBL10800802 0.99 ADRB3 (0.69) ADRB3ADRB1
Hydrochloric Acid SCHEMBL9316504 0.99 ADRB3 (0.69) ADRB3ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0403360-B1 Use of phenylethanolamines for the preparation of a medicament for treating ophthalmologic disorders SANOFI SA (FR) 1996-10-16 EP claimed
EP-0303546-B1 O-alkylation process for N-(hydroxy)aralkyl phenyl ethanol amines SANOFI SA (FR) 1994-12-28 EP claimed
EP-0403360-B1 Use of phenylethanolamines for the preparation of a medicament for treating ophthalmologic disorders SANOFI SA (FR) 1996-10-16 EP disclosed
EP-0303546-B1 O-alkylation process for N-(hydroxy)aralkyl phenyl ethanol amines SANOFI SA (FR) 1994-12-28 EP disclosed
US-5347037-A (RR) and (RS stereoisomers of N-(7-ethoxycarbonylmethoxy-1,2,3,-tetrahydronaphth-2-yl)-2-(3-chlorophenyl)-2-hydroxyethanamine and their pharmaceutically acceptable salts SANOFI (FR) 1994-09-13 US disclosed
US-5235103-A Process for the preparation of phenylethanolaminotetralins SANOFI (FR) 1993-08-10 US disclosed
US-5198586-A Process for the preparation of phenylethanolaminotetralins SANOFI (FR) 1993-03-30 US disclosed
EP-0303545-B1 PROCESS FOR THE PREPARATION OF PHENYLETHANOLAMINOTETRALINES ELF SANOFI (FR) 1992-06-17 EP disclosed
US-5041606-A Process for the O-alkylation of N-(hydroxy)aralkylphenylethanolamines SANOFI 1991-08-20 US disclosed
US-4927955-A Process for the O-alkylation of N-(hydroxy)aralkylphenylethanolamines SANOFI (FR) 1990-05-22 US disclosed
EP-0303546-A2 O-alkylation process for N-(hydroxy)aralkyl phenyl ethanol amines SANOFI (FR) 1989-02-15 EP disclosed
EP-0303545-A2 Process for the preparation of phenylethanolaminotetralines ELF SANOFI (FR) 1989-02-15 EP disclosed