Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9006823 | 1.00 | DPP4 (0.66) | DPP4ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL10876026 | 1.00 | DPP4 (0.66) | DPP4ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL11464633 | 1.00 | DPP4 (0.66) | DPP4ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL9006817 | 1.00 | DPP4 (0.66) | DPP4ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL9006829 | 1.00 | DPP4 (0.66) | DPP4ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL10725864 | 1.00 | DPP4 (0.66) | DPP4ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL10730093 | 1.00 | DPP4 (0.66) | DPP4ADRB1ADRB2ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL11465154 | 0.99 | DPP4 (0.65) | DPP4ADRB1ADRB2ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL10564269 | 0.99 | DPP4 (0.65) | DPP4ADRB1ADRB2ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL11465153 | 0.99 | DPP4 (0.65) | DPP4ADRB1ADRB2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0403360-B1 | Use of phenylethanolamines for the preparation of a medicament for treating ophthalmologic disorders | SANOFI SA (FR) | 1996-10-16 | — | — | EP | claimed |
| US-5236951-A | Administering a phenylethanolamine derivative | SANOFI (FR) | 1993-08-17 | — | — | US | claimed |
| EP-0255415-B1 | USE OF PHENYLETHANOLAMINES FOR THE PREPARATION OF MEDICAMENTS ACTING ON GASTROINTESTINAL TROUBLES | ELF SANOFI (FR) | 1993-04-14 | — | — | EP | claimed |
| US-5002946-A | Gastrointestinal diseases associated with smooth muscle contractions | SANOFI (FR) | 1991-03-26 | — | — | US | claimed |
| US-4845127-A | ANTIBESITY | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | claimed |
| EP-0255415-A2 | Use of phenylethanolamines for the preparation of medicaments acting on gastrointestinal troubles | ELF SANOFI (FR) | 1988-02-03 | — | — | EP | claimed |
| US-4391826-A | DIETETICS | ELI LILLY AND COMPANY (US) | 1983-07-05 | — | — | US | claimed |
| EP-0007204-B1 | PHENETHANOLAMINES, THEIR FORMULATIONS, USE AND PREPARATION | ELI LILLY AND COMPANY (US) | 1982-11-24 | — | — | EP | claimed |
| EP-0007204-A1 | Phenethanolamines, their formulations, use and preparation | ELI LILLY AND COMPANY (US) | 1980-01-23 | — | — | EP | claimed |
| EP-0403360-B1 | Use of phenylethanolamines for the preparation of a medicament for treating ophthalmologic disorders | SANOFI SA (FR) | 1996-10-16 | — | — | EP | disclosed |
| US-5236951-A | Administering a phenylethanolamine derivative | SANOFI (FR) | 1993-08-17 | — | — | US | disclosed |
| EP-0255415-B1 | USE OF PHENYLETHANOLAMINES FOR THE PREPARATION OF MEDICAMENTS ACTING ON GASTROINTESTINAL TROUBLES | ELF SANOFI (FR) | 1993-04-14 | — | — | EP | disclosed |
| US-5002946-A | Gastrointestinal diseases associated with smooth muscle contractions | SANOFI (FR) | 1991-03-26 | — | — | US | disclosed |
| EP-0403360-A2 | Use of phenylethanolamines for the preparation of a medicament for treating ophthalmologic disorders | SANOFI (FR) | 1990-12-19 | — | — | EP | disclosed |
| US-4652679-A | Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0094595-B1 | AZIRIDINE AND PHENYLETHANOL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-01-14 | — | — | EP | disclosed |
| US-4585796-A | HYPOGLYCEMIC, ANTI-OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1986-04-29 | — | — | US | disclosed |
| US-4391826-A | DIETETICS | ELI LILLY AND COMPANY (US) | 1983-07-05 | — | — | US | disclosed |
| EP-0007204-B1 | PHENETHANOLAMINES, THEIR FORMULATIONS, USE AND PREPARATION | ELI LILLY AND COMPANY (US) | 1982-11-24 | — | — | EP | disclosed |
| EP-0048037-A1 | Optically active 1-alkyl-3-(4-substituted-phenyl)-propylamines | ELI LILLY AND COMPANY (US) | 1982-03-24 | — | — | EP | disclosed |