Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.31 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5736909 | 0.87 | AKR1B1 (0.35) | AKR1B1CYP26A1CYP26B1FTO | |
| SCHEMBL9006905 | 0.80 | AKR1B1 (0.32) | AKR1B1CYP26A1FTO | |
| SCHEMBL7218162 | 0.76 | CYP26A1 (0.42) | AKR1B1CYP26A1CYP26B1FTO | |
| SCHEMBL9484220 | 0.75 | RARB (0.41) | CYP26A1 | |
| SCHEMBL9007036 | 0.75 | RARB (0.60) | CYP26A1 | |
| SCHEMBL9054386 | 0.75 | MAPT (0.42) | AKR1B1CYP26A1CYP26B1FTO | |
| SCHEMBL8759623 | 0.75 | BACE1 (0.42) | AKR1B1CYP26A1CYP26B1FTO | |
| SCHEMBL8561808 | 0.73 | AKR1B1 (0.33) | AKR1B1CYP26A1CYP26B1FTO | |
| SCHEMBL5735185 | 0.72 | — | — | |
| SCHEMBL9007040 | 0.71 | AKR1B1 (0.36) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0571546-B1 | CHROMAN AND THIOCHROMANS WITH PHENYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN INC (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5346915-A | Chromans and thiochromans with phenylethynyl substituents at the 7-position having retinold-like biological activity | ALLERGAN, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5346895-A | Treating dermatoses, immunological disorders, wound healing | ALLERGAN, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0577737-A1 | CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1994-01-12 | — | — | EP | disclosed |
| WO-1992017471-A1 | CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1992-10-15 | — | — | WO | disclosed |