Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 10/20 | 0.51 |
| ▸ | DDO | Q99489 | 5/20 | 0.51 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9393175 | 0.83 | DAO (0.49) | DAODDOGPR17KDM4E | |
| SCHEMBL9393343 | 0.79 | DAO (0.46) | DAODDOGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9387612 | 0.78 | DAO (0.66) | DAODDO | |
| SCHEMBL9389006 | 0.75 | DAO (0.54) | DAODDO | |
| SCHEMBL8873562 | 0.74 | DAO (0.51) | DAODDOKDM4EGRIN2DGRIN3B | |
| SCHEMBL312015 | 0.73 | MEN1 (0.46) | KDM4E | |
| SCHEMBL9007832 | 0.72 | DAO (0.65) | DAODDOKDM4E | |
| SCHEMBL9387834 | 0.72 | DAO (0.46) | DAODDOGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9387925 | 0.71 | DAO (0.53) | DAODDO | |
| SCHEMBL8873456 | 0.71 | GPR17 (0.38) | DAODDOGPR17KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0517876-B1 | THERAPEUTIC BENZAZEPINE COMPOUNDS | ZENECA LTD (GB) | 1996-10-23 | — | — | EP | claimed |
| US-5446039-A | Treating nervous system and brain disorder, acting as excitatory amino acid antagonist | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1995-08-29 | — | — | US | claimed |
| US-5254683-A | Neurological disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | claimed |
| WO-1992011854-A1 | THERAPEUTIC BENZAZEPINE COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-23 | — | — | WO | claimed |
| EP-0517876-B1 | THERAPEUTIC BENZAZEPINE COMPOUNDS | ZENECA LTD (GB) | 1996-10-23 | — | — | EP | disclosed |
| US-5541319-A | REACTING SUBSTITUTED BENZAZEPINE ETHER WITH BORON TRIHALIDE TO FORM HYDROXY GROUP, FORMING SALT WITH BASE IF DESIRED | ZENECA LIMITED (GB) | 1996-07-30 | — | — | US | disclosed |
| US-5446039-A | Treating nervous system and brain disorder, acting as excitatory amino acid antagonist | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1995-08-29 | — | — | US | disclosed |
| WO-1994007500-A1 | 2,5-DIHYDRO-2,5-DIOXO-1H-AZEPINES AND 2,5-DIHYDRO-2-OXO-1H-AZEPINES AND THE USE THEREOF AS EXCITATORY AMINO ACID AND GLYCINE RECEPTOR ANTAGONISTS | WEBER ECKARD (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5254683-A | Neurological disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0517876-A1 | THERAPEUTIC BENZAZEPINE COMPOUNDS. | ICI PLC (GB) | 1992-12-16 | — | — | EP | disclosed |
| WO-1992011854-A1 | THERAPEUTIC BENZAZEPINE COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-23 | — | — | WO | disclosed |