Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7752010 | 0.83 | — | — | |
| Fumaric Acid SCHEMBL27327513 | 0.83 | TSHR (0.56) | ABCC4MAPTLMNATSHRALDH1A1 | |
| Bicarbonate SCHEMBL28258484 | 0.81 | — | — | |
| Bicarbonate SCHEMBL2030338 | 0.81 | — | — | |
| Maleic Acid SCHEMBL21359069 | 0.81 | TSHR (0.53) | ABCC4MAPTLMNATSHRALDH1A1 | |
| Bicarbonate SCHEMBL31378512 | 0.81 | TSHR (0.71) | ABCC4MAPTLMNATSHRALDH1A1 | |
| Bicarbonate SCHEMBL997243 | 0.81 | — | — | |
| Bicarbonate SCHEMBL28769393 | 0.81 | — | — | |
| SCHEMBL23732 | 0.78 | — | — | |
| SCHEMBL8852489 | 0.78 | TSHR (0.54) | ABCC4MAPTTSHRCA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302712-B1 | Novel copolycarbonate | ASAHI CHEMICAL IND (JP) | 1996-11-13 | — | — | EP | disclosed |
| US-5070173-A | POLYCARBONATEURETHANE THERMOPLASTIC ELASTOMERS; RESISTANT TO H YDROLYSIS, LIGHT, CHLORINE AND OXIDATION | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1991-12-03 | — | — | US | disclosed |
| US-4855377-A | Novel copolycarbonate | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1989-08-08 | — | — | US | disclosed |