Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14973711 | 0.83 | PDE10A (1.00) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14985172 | 0.83 | PDE10A (1.00) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL10086109 | 0.80 | PDE10A (1.00) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL19281171 | 0.71 | PDE10A (0.69) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14974475 | 0.71 | PDE10A (0.69) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14973890 | 0.71 | PDE10A (0.69) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14973852 | 0.70 | PDE10A (0.79) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14982004 | 0.70 | PDE10A (0.79) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14973824 | 0.69 | PDE10A (1.00) | PDE10ANR1I2CYP2C9 | |
| SCHEMBL14974302 | 0.69 | PDE10A (1.00) | PDE10ANR1I2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044562-A2 | PYRAZOLOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |