Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | CMA1 | P23946 | 4/20 | 0.40 |
| ▸ | TMPRSS11D | O60235 | 7/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | PLG | P00747 | 3/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.39 |
| ▸ | XIAP | P98170 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012024 | 1.00 | F2 (0.44) | F2PRSS1CMA1TMPRSS11DF10 | |
| SCHEMBL9012414 | 0.93 | F2 (0.45) | F2PRSS1CMA1TMPRSS11DF10 | |
| SCHEMBL9012061 | 0.92 | F2 (0.45) | F2PRSS1CMA1TMPRSS11DF10 | |
| SCHEMBL9012058 | 0.92 | F2 (0.45) | F2PRSS1CMA1TMPRSS11DF10 | |
| SCHEMBL9012256 | 0.92 | F2 (0.44) | F2PRSS1CMA1TMPRSS11DF10 | |
| SCHEMBL9012271 | 0.92 | F2 (0.44) | F2PRSS1CMA1TMPRSS11DF10 | |
| SCHEMBL9012354 | 0.91 | F2 (0.40) | F2PRSS1CMA1ACEACE2 | |
| SCHEMBL9012366 | 0.91 | F2 (0.40) | F2PRSS1CMA1ACEACE2 | |
| SCHEMBL9011985 | 0.90 | F2 (0.43) | F2PRSS1CMA1TMPRSS11DF10 | |
| SCHEMBL9012265 | 0.90 | F2 (0.43) | F2PRSS1CMA1TMPRSS11DF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | claimed |
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |