Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.39 |
| ▸ | TMPRSS11D | O60235 | 7/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | PLG | P00747 | 3/20 | 0.39 |
| ▸ | ACE | P12821 | 4/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012454 | 0.90 | F2 (0.48) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9012445 | 0.90 | F2 (0.48) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9012260 | 0.89 | F2 (0.47) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9012194 | 0.89 | F2 (0.47) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9012244 | 0.89 | F2 (0.47) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9012191 | 0.89 | F2 (0.47) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9012127 | 0.88 | F2 (0.40) | F2PRSS1ACEACE2PRSS2 | |
| SCHEMBL9012414 | 0.87 | F2 (0.45) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9012355 | 0.87 | F2 (0.51) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9012346 | 0.87 | F2 (0.51) | F2PRSS1TMPRSS11DF10PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | claimed |
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |