Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.46 |
| ▸ | F2 | P00734 | 6/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.38 |
| ▸ | TMPRSS11D | O60235 | 2/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9012560 | 1.00 | ACE (0.46) | ACEACE2F2PRCPCMA1 | |
| SCHEMBL9012364 | 0.96 | ACE (0.46) | ACEACE2F2PRCPCMA1 | |
| SCHEMBL9012094 | 0.96 | ACE (0.46) | ACEACE2F2PRCPCMA1 | |
| SCHEMBL9012022 | 0.95 | ACE (0.45) | ACEACE2F2PRCPCMA1 | |
| SCHEMBL9012014 | 0.95 | ACE (0.45) | ACEACE2F2PRCPCMA1 | |
| SCHEMBL9012026 | 0.93 | ACE (0.43) | ACEACE2F2PRCPCMA1 | |
| SCHEMBL9012029 | 0.93 | ACE (0.43) | ACEACE2F2PRCPCMA1 | |
| SCHEMBL9012505 | 0.93 | ACE (0.43) | ACEACE2F2PRCPCMA1 | |
| SCHEMBL9012494 | 0.93 | ACE (0.43) | ACEACE2F2PRCPCMA1 | |
| SCHEMBL9012200 | 0.92 | ACE (0.42) | ACEACE2F2PRCPCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743320-A2 | Acyl guanidine and amidine prodrugs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-11-20 | — | — | EP | claimed |