Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28313838 | 0.90 | NPSR1 (0.33) | NPSR1MEN1KMT2ACYP3A4LMNA | |
| SCHEMBL9468144 | 0.88 | NPSR1 (0.42) | NPSR1MEN1KMT2ACYP3A4LMNA | |
| SCHEMBL28524151 | 0.79 | NPSR1 (0.35) | NPSR1MEN1KMT2ACYP3A4LMNA | |
| SCHEMBL418071 | 0.79 | NPSR1 (0.39) | NPSR1MEN1KMT2ACYP3A4CYP4F2 | |
| SCHEMBL28603680 | 0.77 | CYP3A4 (0.37) | NPSR1MEN1KMT2ACYP3A4LMNA | |
| SCHEMBL27944652 | 0.75 | CYP3A4 (0.36) | NPSR1MEN1KMT2ACYP3A4LMNA | |
| SCHEMBL28858252 | 0.74 | MEN1 (0.35) | NPSR1MEN1KMT2ACYP3A4LMNA | |
| SCHEMBL8150683 | 0.72 | — | — | |
| SCHEMBL29216813 | 0.72 | MEN1 (0.38) | NPSR1MEN1KMT2ACYP3A4 | |
| SCHEMBL126906 | 0.72 | FFAR3 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |