Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494939 | 0.83 | HPGD (0.52) | KDM4EMAPTTHRBHPGDGPR119 | |
| SCHEMBL27153425 | 0.82 | KDM4E (0.44) | KDM4EPKMDDB1CRBNMAPT | |
| SCHEMBL6608848 | 0.82 | HPGD (0.53) | KDM4EPKMGLSMAPTTHRB | |
| SCHEMBL106242 | 0.79 | KDM4E (0.52) | KDM4EPKMGLSHPGDGPR119 | |
| SCHEMBL22009028 | 0.79 | BRD4 (0.39) | MAPT | |
| SCHEMBL12995623 | 0.79 | USP2 (0.49) | KDM4EDDB1CRBNMAPTTHRB | |
| SCHEMBL6150378 | 0.79 | BACE1 (0.51) | KDM4EPKMDDB1CRBNMAPT | |
| Hydrochloric Acid SCHEMBL4219415 | 0.78 | KDM4E (0.51) | KDM4EPKMGLSHPGDGPR119 | |
| SCHEMBL12071961 | 0.78 | HPGD (0.50) | KDM4EMAPTTHRBHPGDGPR119 | |
| SCHEMBL32682848 | 0.78 | DDB1 (0.49) | KDM4EDDB1CRBNMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580883-A | INHIBITING DEGENERATION AND NECROCYTOSIS OF CEREBRAL NERVE CELLS CAUSED BY OXIDATIVE STRESS INDUCING GLUTAMIC ACID IN MAMMALS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0449195-B1 | Aminobenzene compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0449195-A2 | Aminobenzene compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |