Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.44 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901729 | 0.90 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1NAMPTPREP | |
| SCHEMBL904085 | 0.88 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1NAMPT | |
| Hydrochloric Acid SCHEMBL15091355 | 0.86 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1NAMPTDPP8DPP7 | |
| SCHEMBL902377 | 0.86 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1NAMPTDPP8DPP7 | |
| SCHEMBL10255169 | 0.86 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1NAMPTDPP8DPP7 | |
| SCHEMBL901832 | 0.86 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1NAMPT | |
| Hydrochloric Acid SCHEMBL15091340 | 0.86 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1NAMPTDPP8DPP7 | |
| Hydrochloric Acid SCHEMBL15091335 | 0.85 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1NAMPT | |
| SCHEMBL904227 | 0.85 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1PREPDPP8DPP7 | |
| SCHEMBL902181 | 0.85 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621919-A1 | PHENYLQUINAZOLINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041435-A1 | PHENYLQUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-04-05 | — | — | WO | disclosed |