Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 12/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.40 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015055 | 1.00 | SERPINE1 (0.67) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6380172 | 0.86 | SERPINE1 (0.74) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6380170 | 0.86 | SERPINE1 (0.74) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6375268 | 0.83 | SERPINE1 (0.70) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6375264 | 0.83 | SERPINE1 (0.70) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8494433 | 0.83 | SERPINE1 (0.65) | SERPINE1HRH3CYP2D6 | |
| Dimethylamine SCHEMBL6378373 | 0.83 | SERPINE1 (0.65) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30388925 | 0.83 | SERPINE1 (0.65) | SERPINE1HRH3CYP2D6 | |
| SCHEMBL6375596 | 0.83 | SERPINE1 (0.65) | SERPINE1HRH3CYP2D6 | |
| Hydrochloric Acid SCHEMBL6374524 | 0.82 | SERPINE1 (0.64) | SERPINE1HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745069-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | claimed |
| WO-1995021829-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |