Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 10/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249630 | 1.00 | HDAC8 (0.50) | HDAC8TBXA2RPSEN1PSEN2APH1B | |
| SCHEMBL9015505 | 0.83 | TBXA2R (0.53) | HDAC8TBXA2RHTT | |
| SCHEMBL9015504 | 0.83 | TBXA2R (0.53) | HDAC8TBXA2RHTT | |
| SCHEMBL9015393 | 0.83 | TBXA2R (0.48) | HDAC8TBXA2RPSEN1PSEN2APH1B | |
| SCHEMBL9015391 | 0.83 | TBXA2R (0.48) | HDAC8TBXA2RPSEN1PSEN2APH1B | |
| SCHEMBL9252986 | 0.81 | TBXA2R (0.46) | HDAC8TBXA2RHTTALDH1A1 | |
| SCHEMBL9248473 | 0.81 | HDAC8 (0.45) | HDAC8TBXA2RPSEN1PSEN2APH1B | |
| SCHEMBL9252991 | 0.81 | TBXA2R (0.46) | HDAC8TBXA2RHTTALDH1A1 | |
| SCHEMBL9248467 | 0.81 | HDAC8 (0.45) | HDAC8TBXA2RPSEN1PSEN2APH1B | |
| SCHEMBL9834723 | 0.79 | HDAC8 (0.54) | HDAC8TBXA2RPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0648741-B1 | 1,2,3,4-Tetrahydronaphthalene, chroman and thiochroman derivatives as antithrombotic agents | ADIR (FR) | 1996-12-18 | — | — | EP | disclosed |
| US-5472979-A | Antithrombotics | ADIR ET COMPAGNIE (FR) | 1995-12-05 | — | — | US | disclosed |
| EP-0648741-A1 | 1,2,3,4-Tetrahydronaphthalene, chroman and thiochroman derivatives as antithrombotic agents | ADIR ET COMPAGNIE (FR) | 1995-04-19 | — | — | EP | disclosed |