Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017484 | 0.85 | AKR1C2 (0.56) | ALDH1A1HSD17B10AKR1C2PTPN5MAPT | |
| SCHEMBL6013496 | 0.85 | AKR1C2 (0.49) | ALDH1A1HPGDHSD17B10AKR1C2SLC2A1 | |
| SCHEMBL998208 | 0.84 | AKR1C2 (0.46) | ALDH1A1HPGDAKR1C2MAPTKDM4E | |
| SCHEMBL27603211 | 0.80 | SLC2A1 (0.54) | ALDH1A1AKR1C2SLC2A1MAPTKDM4E | |
| SCHEMBL9017471 | 0.78 | AKR1C2 (0.47) | ALDH1A1AKR1C2SLC2A1MAPTKDM4E | |
| SCHEMBL9017473 | 0.78 | AKR1C2 (0.47) | ALDH1A1AKR1C2MAPTKDM4EGAA | |
| SCHEMBL5499426 | 0.77 | AKR1C2 (0.48) | ALDH1A1AKR1C2MAPTKDM4EGAA | |
| SCHEMBL5496301 | 0.77 | AKR1C2 (0.46) | ALDH1A1AKR1C2SLC2A1MAPTKDM4E | |
| SCHEMBL7755896 | 0.76 | AKR1C2 (0.43) | ALDH1A1HPGDHSD17B10AKR1C2MAPT | |
| SCHEMBL11466556 | 0.76 | MAPT (0.45) | ALDH1A1HSD17B10AKR1C2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995022524-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-24 | — | — | WO | disclosed |