Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018409 | 0.94 | MAPT (0.49) | CYP3A4CYP2C9CYP2C19LMNAHTR1A | |
| SCHEMBL9018314 | 0.89 | MAPT (0.49) | CYP3A4CYP2C9CYP2C19LMNAHTR1A | |
| SCHEMBL9139724 | 0.88 | CYP3A4 (0.49) | CYP3A4CYP2C9CYP2C19LMNAHTR1A | |
| SCHEMBL9018074 | 0.87 | MAPT (0.45) | CYP3A4CYP2C9CYP2C19LMNAHTR1A | |
| SCHEMBL9018297 | 0.86 | TSHR (0.46) | CYP3A4CYP2C9CYP2C19LMNAHTR1A | |
| SCHEMBL9018006 | 0.86 | MAPT (0.44) | CYP3A4CYP2C9CYP2C19LMNAHTR1A | |
| SCHEMBL9018338 | 0.86 | MAPT (0.44) | CYP3A4CYP2C9CYP2C19LMNAHTR1A | |
| SCHEMBL7871341 | 0.85 | MAPT (0.46) | CYP3A4CYP2C9CYP2C19LMNAHTR1A | |
| SCHEMBL7870460 | 0.84 | MAPT (0.44) | CYP3A4CYP2C9CYP2C19LMNAHTR1A | |
| SCHEMBL7868035 | 0.83 | MAPT (0.43) | CYP3A4CYP2C9CYP2C19LMNAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |