Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018137 | 0.94 | POLB (0.44) | POLBTDP1MAPTMEN1KMT2A | |
| SCHEMBL9018440 | 0.93 | POLB (0.49) | POLBTDP1MAPTMEN1KMT2A | |
| SCHEMBL9018342 | 0.92 | MEN1 (0.45) | POLBTDP1MAPTMEN1KMT2A | |
| SCHEMBL9018234 | 0.92 | POLB (0.46) | POLBTDP1MAPTMEN1KMT2A | |
| SCHEMBL9018157 | 0.90 | POLB (0.47) | POLBTDP1MAPTMEN1KMT2A | |
| SCHEMBL9017989 | 0.88 | NPC1 (0.48) | MAPTMEN1KMT2AP4HTM | |
| SCHEMBL9018380 | 0.88 | MEN1 (0.46) | MAPTMEN1KMT2AP4HTM | |
| SCHEMBL9018182 | 0.87 | CA1 (0.54) | MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9018256 | 0.86 | KMT2A (0.52) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9018402 | 0.86 | POLB (0.45) | POLBTDP1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |