Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.35 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004004 | 0.80 | KCNQ3 (0.39) | KCNQ3KCNQ2KCNQ5PLAUCA2 | |
| SCHEMBL7995261 | 0.76 | TTR (0.61) | TTRGCKNPSR1ALDH1A1PKM | |
| SCHEMBL8499411 | 0.74 | GCK (0.42) | TTRF10PLAUGCKPKM | |
| SCHEMBL9018660 | 0.73 | POLB (0.33) | KCNQ3KCNQ2ALDH1A1KDM4ECA2 | |
| Hydrochloric Acid SCHEMBL8743784 | 0.73 | GCK (0.42) | TTRF10PLAUGCKPKM | |
| SCHEMBL8815218 | 0.71 | NR4A2 (0.58) | PKM | |
| SCHEMBL8004007 | 0.70 | C5AR1 (0.37) | KCNQ3KCNQ2KCNQ5CA2 | |
| SCHEMBL8073502 | 0.70 | TTR (0.51) | TTRNPSR1ALDH1A1PKMCA2 | |
| SCHEMBL8004812 | 0.70 | KCNQ3 (0.42) | KCNQ3KCNQ2F2ALDH1A1CA2 | |
| Hydrochloric Acid SCHEMBL8743786 | 0.70 | SCN2A (0.48) | F2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748795-A2 | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-18 | — | — | EP | disclosed |