SCHEMBL9018748

SCHEMBL9018748

O=C(Oc1ccccc1)C(CCCP)(c1ccccc1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 3/20 0.39
SCN2A Q99250 3/20 0.39
SCN3A Q9NY46 3/20 0.39
LMNA P02545 2/20 0.39
CYP1A2 P05177 2/20 0.39
CYP3A4 P08684 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
TSHR P16473 1/20 0.39
NFKB1 P19838 1/20 0.39
MTOR P42345 1/20 0.39
RAB9A P51151 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
HSD17B10 Q99714 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
NR1I2 O75469 1/20 0.38
CYP1A1 P04798 1/20 0.38
CYP2E1 P05181 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL11623452 0.98 SCN1A (0.38) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL2974221 0.90 SCN1A (0.40) SCN1ASCN2ASCN3ALMNACYP1A2
Bromide SCHEMBL9938236 0.82 SCN1A (0.46) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL2987922 0.81 SCN1A (0.57) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL7021328 0.81 CYP2C9 (0.36) SCN1ASCN2ASCN3ALMNACYP1A2
Bromide SCHEMBL10984916 0.81 SCN1A (0.45) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL27262733 0.77 CHRM2 (0.55) SCN1ASCN2ASCN3ALMNACYP1A2
Phosphine SCHEMBL27817567 0.76 CHRM2 (0.54) SCN1ASCN2ASCN3ALMNACYP1A2
Acetic Acid SCHEMBL27305465 0.74 CHRM2 (0.52) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL29152870 0.73 CHRM2 (0.48) SCN1ASCN2ASCN3ALMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749437-A1 STEROID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR PHARMACEUTICAL USES MAGAININ PHARMACEUTICALS INC. (US) 1996-12-27 EP disclosed
WO-1995024415-A1 STEROID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR PHARMACEUTICAL USES MAGAININ PHARMACEUTICALS INC. (US) 1995-09-14 WO disclosed
US-4071530-A Pyrrolidones and process for preparing them HOECHST AKTIENGESELLSCHAFT (DT) 1978-01-31 US disclosed