Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12893944 | 0.83 | ROCK1 (0.53) | KMT2AKDM4EMEN1HPGDRXFP1 | |
| SCHEMBL1505883 | 0.82 | MEN1 (0.64) | KMT2AKDM4EMEN1HPGDRXFP1 | |
| SCHEMBL583270 | 0.79 | KDM4E (0.64) | KMT2AKDM4EMEN1HPGDRXFP1 | |
| SCHEMBL13227847 | 0.78 | KMT2A (0.78) | KMT2AKDM4EMEN1HPGDRXFP1 | |
| SCHEMBL23999861 | 0.76 | KMT2A (0.57) | KMT2AKDM4EMEN1HPGDRXFP1 | |
| SCHEMBL28590406 | 0.76 | KMT2A (0.54) | KMT2AKDM4EMEN1HPGDRXFP1 | |
| SCHEMBL71303 | 0.75 | TSHR (0.69) | KMT2AMEN1HPGDSMN1; SMN2TSHR | |
| SCHEMBL13955869 | 0.74 | KMT2A (0.72) | KMT2AKDM4EMEN1HPGDRXFP1 | |
| SCHEMBL22235430 | 0.74 | CA1 (0.55) | KMT2AKDM4EMEN1HPGDRXFP1 | |
| SCHEMBL5415723 | 0.74 | MEN1 (0.74) | KMT2AKDM4EMEN1HPGDRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |