Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.67 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089121 | 0.92 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2ALOX5GPBAR1FFAR1 | |
| SCHEMBL9053241 | 0.92 | CYSLTR1 (0.73) | CYSLTR1CYSLTR2ALOX5GPBAR1FFAR1 | |
| SCHEMBL7458734 | 0.91 | CYSLTR1 (0.68) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL1419872 | 0.91 | FFAR1 (0.77) | CYSLTR1CYSLTR2ALOX5GPBAR1FFAR1 | |
| SCHEMBL7711072 | 0.88 | GPBAR1 (0.80) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL7807149 | 0.87 | FFAR1 (0.68) | CYSLTR1CYSLTR2ALOX5GPBAR1FFAR1 | |
| SCHEMBL6088484 | 0.86 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL10543161 | 0.86 | CYSLTR1 (0.74) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL6089254 | 0.85 | CYSLTR1 (0.67) | CYSLTR1CYSLTR2ALOX5GPBAR1FFAR1 | |
| SCHEMBL7716691 | 0.85 | CYSLTR1 (0.88) | CYSLTR1CYSLTR2ALOX5GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315399-B1 | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same | RHONE POULENC RORER INT (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5059610-A | QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |