Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.69 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.69 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.60 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10536253 | 0.92 | CYSLTR1 (0.58) | CYSLTR1GPBAR1FFAR1CYSLTR2KDM4E | |
| SCHEMBL7711072 | 0.86 | GPBAR1 (0.80) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9023239 | 0.84 | CYSLTR1 (0.82) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL7716691 | 0.84 | CYSLTR1 (0.88) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL7010155 | 0.84 | CYSLTR1 (0.80) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10536262 | 0.84 | CYSLTR1 (0.52) | CYSLTR1GPBAR1CYSLTR2KDM4EMEN1 | |
| SCHEMBL14044001 | 0.83 | FFAR1 (0.79) | FFAR1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL7454134 | 0.82 | CYSLTR1 (0.64) | CYSLTR1GPBAR1CYSLTR2KDM4EMEN1 | |
| SCHEMBL422355 | 0.82 | CYSLTR1 (1.00) | CYSLTR1GPBAR1CYSLTR2KDM4EMEN1 | |
| SCHEMBL30444017 | 0.82 | CYSLTR1 (1.00) | CYSLTR1GPBAR1CYSLTR2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315399-B1 | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same | RHONE POULENC RORER INT (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5059610-A | QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |