⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7162800 | 0.87 | — | — | |
| SCHEMBL29496072 | 0.75 | — | — | |
| SCHEMBL29280203 | 0.67 | — | — | |
| SCHEMBL19134040 | 0.65 | — | — | |
| SCHEMBL31319992 | 0.57 | — | — | |
| SCHEMBL17838695 | 0.53 | — | — | |
| SCHEMBL641884 | 0.47 | — | — | |
| SCHEMBL27633682 | 0.47 | — | — | |
| Water SCHEMBL490048 | 0.34 | — | — | |
| SCHEMBL56545 | 0.33 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 533 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040102423-A1 | Spironolactone and angiotensin II antagonist combination therapy for treatment of congestive heart failure | G.D. SEARLE & CO. | 2004-05-27 | — | — | US | claimed |
| US-20040067915-A1 | Method to treat cardiofibrosis with a combination of an angiotensin II antagonist and spironolactone | G.D. SEARLE & CO. (US) | 2004-04-08 | — | — | US | claimed |
| US-20040053903-A1 | Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and an epoxy-steroidal aldosterone antagonist | G.D. SEARLE & CO. | 2004-03-18 | — | — | US | claimed |
| US-6653306-B1 | Circulatory disorders | G.D. SEARLE & CO. | 2003-11-25 | — | — | US | claimed |
| EP-0831911-A2 | SPIRONOLACTONE AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE | G.D. SEARLE & CO. (US) | 1998-04-01 | — | — | EP | claimed |
| EP-0831910-A1 | EPOXY-STEROIDAL ALDOSTERONE ANTAGONIST AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE | G.D. SEARLE & CO. (US) | 1998-04-01 | — | — | EP | claimed |
| WO-1996040258-A2 | SPIRONOLACTONE AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE | G.D. SEARLE & CO. (US) | 1996-12-19 | — | — | WO | claimed |
| WO-1996040257-A1 | EPOXY-STEROIDAL ALDOSTERONE ANTAGONIST AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE | G.D. SEARLE & CO. (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0300850-B1 | 1-ARYLSULFONYL-1,5-DIHYDRO 2H-PYRROL-2-ONE DERIVATIVES, INTERMEDIATES AND PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-08-26 | — | — | EP | claimed |
| EP-0298818-B1 | 1-BENZENESULFONYL 2-OXO 5-ALKYLTHIO PYRROLIDINES, PROCESS FOR THEIR PREPARATION, THEIR INTERMEDIARIES AND THEIR USE AS MEDICINES | ROUSSEL-UCLAF (FR) | 1992-08-26 | — | — | EP | claimed |
| EP-0229566-B1 | 1-BENZENE SULFONYL 2-OXO-5-ALKOXY PYRROLIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINE AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-05-06 | — | — | EP | claimed |
| EP-0239500-B1 | 1-STYRENE-SULFONYL-2-OXO-5-HYDROXY-PYRROLIDINE DERIVATIVES, THEIR INTERMEDIATES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES | ROUSSEL-UCLAF (FR) | 1992-01-22 | — | — | EP | claimed |
| EP-0296979-B1 | 1-BENZOYL-2-OXO-5-ALKOXY-PYRROLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PREPARATIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-12-04 | — | — | EP | claimed |
| EP-0296978-B1 | 1-BENZYL 2-OXO 5-ALKOXY PYRROLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE IN MEDICINES | ROUSSEL-UCLAF (FR) | 1991-09-11 | — | — | EP | claimed |
| US-20240239790-A1 | 7-Morpholino-1,6-Naphthyridin-5-yl Derivatives and Pharmaceutical Compositions Thereof Useful as DNA-PK Inhibitor | LIFEARC (GB) | 2024-07-18 | — | — | US | disclosed |
| WO-2024149990-A1 | NIRMATRELVIR ANALOGS AS 3C LIKE PROTEASE INHIBITORS FOR TREATING VIRAL INFECTIONS | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2024-07-18 | — | — | WO | disclosed |
| CN-118317954-A | Indoline as PROTAC compound | 奈奥芬莱有限公司 | 2024-07-09 | — | — | CN | disclosed |
| EP-0298818-A1 | 1-Benzenesulfonyl 2-oxo 5-alkylthio pyrrolidines, process for their preparation, their intermediaries and their use as medicines | ROUSSEL-UCLAF (FR) | 1989-01-11 | — | — | EP | disclosed |
| EP-0296979-A2 | 1-Benzoyl-2-oxo-5-alkoxy-pyrrolidine derivatives, their preparation, their use and preparations containing them | ROUSSEL-UCLAF (FR) | 1988-12-28 | — | — | EP | disclosed |
| EP-0296978-A2 | 1-Benzyl 2-oxo 5-alkoxy pyrrolidine derivatives, process for their preparation, compositions containing them and their use in medicines | ROUSSEL-UCLAF (FR) | 1988-12-28 | — | — | EP | disclosed |